화학공학소재연구정보센터
Applied Chemistry for Engineering, Vol.31, No.5, 545-551, October, 2020
인지질/세라마이드 혼합물의 상호적 자가회합 특성을 활용한 수화 액정형 베시클 제조
Preparation of Hydrated Liquid Crystalline Vesicle Using Mutual Self-Association between Ceramide and Phospholipid
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초록
인지질과 세라마이드 간 상호적 자가회합 특성을 활용하여 수화 액정형 베시클 제조를 시도하였다. 인지질과 세라마이드의 혼합지질에 에지 액티베이터를 첨가하면 난용성의 세라마이드를 고 함량으로 함유하는 베시클 제조가 가능하였다. 본 연구에서는 인지질, 세라마이드, 에지 액티베이터의 혼합 조성에 따른 수화 액정상의 구조적, 열적 특성 등의 변화를 관측하고, 혼합 조성을 달리하여 만든 베시클의 입자크기 및 베시클 분산액의 안정성을 비교하였다. 실험 결과, 인지질과 세라마이드 간 혼합에서 세라마이드 비율을 최대 70%까지 늘려서, 베시클 분산액 전체 대비 세라마이드를 3.5 wt% 함유되는 제형을 제조할 수 있었다.
An attempt was made to prepare hydrated liquid crystalline vesicles by utilizing a mutual self-assembly between phospholipid and ceramide. When an edge activator was added to the mixture of phospholipid and ceramide, it was possible to prepare a vesicle containing a high content of poorly soluble ceramide. In this study, we investigated changes in structural and thermal behaviors of the hydrated liquid crystalline phase according to the mixed composition between phospholipid, ceramide, and sodium deoxycholate. Also, both the droplet size of the vesicles with different composition and stability of the vesicle dispersion solution were observed. From results of the experiments, by increasing the ratio of ceramide up to 70% in the mixture between phospholipid and ceramide, a formulation containing 3.5 wt% of ceramide in the vesicle dispersion solution could be obtained.
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