화학공학소재연구정보센터
Journal of the American Chemical Society, Vol.142, No.22, 9908-9914, 2020
Synthesis of Pyrroles through the CuH-Catalyzed Coupling of Enynes and Nitriles
Herein, we describe an efficient method to prepare polysubstituted pyrroles via a copper hydride (CuH)-catalyzed enyne-nitrile coupling reaction. This protocol accommodates both aromatic and aliphatic substituents and a broad range of functional groups, providing a variety of N-H pyrroles in good yields and with high regioselectivity. We propose that the Cu-based catalyst promotes both the initial reductive coupling and subsequent cyclization steps. Density functional theory (DFT) calculations were performed to elucidate the reaction mechanism.