화학공학소재연구정보센터
Journal of Chemical and Engineering Data, Vol.65, No.6, 3240-3251, 2020
Solubility Determination and Thermodynamic Modeling of Edaravone in Different Solvent Systems and the Solvent Effect in Pure Solvents
The solubility data of edaravone in fourteen neat solvents (water, methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, sec-butanol, n-pentanol, acetone, acetonitrile, dichloromethane, ethyl acetate, and 1,4-dioxane) and three binary solvent mixtures (methanol + water, ethanol + water, and isopropanol + water) were determined by the gravimetric method from 283.15 to 323.15 K. The co-solvency phenomenon was found in the mixed solvents of (ethanol + water) and (isopropanol + water). The solute-solvent and solvent-solvent interactions were analyzed by the KAT-LSER model. In addition, the solubility data were correlated by the modified Apelblat model, Jouyban-Acree model, and Apelblat-Jouyban-Acree model. To choose the best model for correlating the edaravone solubility, the Akaike information criterion values and Akaike weights were calculated for each thermodynamic model.