Journal of Chemical and Engineering Data, Vol.65, No.7, 3690-3695, 2020
Solubility Determination and Model Correlation of Benorilate between T=278.18 and 318.15 K
The objective is to study the solubility of benorilate in 12 pure solvents in the temperature range from 278.15 to 318.15 K by the isothermal saturation method at atmospheric pressure. The solubility increased monotonically with the rising temperature. Moreover, at all evaluated temperatures, the largest solubility value was obtained in N-methyl-2-pyrrolidone, followed by N,N-dimethylformamide > 2-butanone > 1,4-dioxane > acetonitrile > ethyl acetate > 1-butanol > ethanol > methanol > n-propanol > isopropanol > toluene. The solubility values in the reaction solvent (toluene) varied from 1.3 x 10(-5) to 1.08 x 10(-4) in mole fraction between T = 278.15 and 318.15 K, an increase of 8.31-fold. At all evaluated temperatures, the values in ethanol increased from 1.58 x 10(-4) to 9.07 x 10(-4) in mole fraction, an increase of 5.74-fold. Hence, the precipitation and the crystallization purification of benorilate could be effectively controlled by changing the temperature. The obtained solubility data were correlated with the modified Apelblat equation and lambda h equation. The results of relative average deviations indicated that both the lambda h equation and the modified Apelblat equation are capable of describing the solubility of benorilate in selected pure solvents.