Journal of Chemical and Engineering Data, Vol.65, No.7, 3560-3565, 2020
Solubility Measurement and Mathematical Correlation of Ticagrelor in Different Pure Solvents
The solid-liquid phase equilibrium of ticagrelor in methanol, ethanol, npropanol, isopropanol, 1-butanol, isobutanol, n-octanol, acetonitrile, ethyl acetate, toluene, 2-butanone, and cyclohexanone at the temperature range from 273.15 to 313.15 K was measured by using the isothermal dissolution equilibrium method under the pressure of 101.2 kPa. The solubility data were analyzed by high-performance liquid chromatography, and the results increased with the rising temperature. The maximum value was obtained in 2-butanone at 313.15 K (in mole fraction, 7.758 x 10(-2)), and the lowest was in toluene at 273.15 K (in mole fraction, 3.0 x 10(-5)). The result from high to low at all researched temperatures obeyed the following sequence: cyclohexanone > 2-butanone > methanol > ethyl acetate > ethanol > 1-butanol > n-propanol > isopropanol > n-octanol > isobutanol > acetonitrile > toluene. The effect of intermolecular force between the solvent and solute on solubility was analyzed. Moreover, the solubility result in different solvents was correlated by the modified Apelblat equation and lambda h equation. The largest relative average deviation (RAD) value is 2.79% correlated by the lambda h equation in acetonitrile. Compared with experimental and calculated values along with RAD values, the result of the modified Apelblat equation is slightly better than that of the lambda h equation.