Research on heterocyclic compounds with biological and pharmacological activity continues to arouse great interest. The study of 1,4-dihydropyridines (1,4-DHPs) is of particular interest in the pharmaceutical field due to their important applications as calcium channel antagonists for the treatment of heart diseases. The im- plementation of novel heterogeneous catalysts to optimize Hantzsch synthesis, such as ordered mesoporous molecular sieves, is an efficient and eco-friendly proposal that still requires a lot of work. The remarkable features of ordered mesoporous molecular sieves, such as high surface area, tailored porosity, chemical and thermal stability, among others, turn these materials into powerful solid catalysts capable of selectively leading the synthesis of 1,4-DHPs. In addition, the combination of ordered mesoporous molecular sieves and process intensification for the synthesis of 1,4-DHP derivatives is still a research field in development. Therefore, pro- mote greener methodologies in the synthesis of 1,4-DHPs that can be extended to any organic synthesis in fine chemical production is an important goal yet to be achieved.