Process Biochemistry, Vol.89, 71-80, 2020
Antiangiogenic, anti-inflammatory and their antioxidant activities of Turnera subulata Sm. (Turneraceae)
Turners subulata is a substantial medicinal plant used in folk medicine to treat various ailments. The current study was assess the total phenolic and flavonoid contents to evaluate the antioxidant and anti-inflammatory activities of the sequentially extracted T. subulata plant samples. In vitro anti-angiogenic activity was evaluated by chick chorioallantoic membrane (CAM) model for chloroform, ethyl acetate and ethanol extracts. The results obtained revealed that total phenolic content of the chloroform extract (24.13 +/- 0.27 mg/g) and total flavonoid content (TFC) of the chloroform extract (22.28 +/- 0.40 mg/g) were found to be suggestively higher than the other extracts. A strong antioxidant property was observed for all the six extracts. A study anti-inflammatory activity was observed in chloroform and ethanol extracts, with IC50 ranging from 79 +/- 1.01 mu g/mL to 81 +/- 1.01 mu g/mL for protein denaturation assay and from 74 +/- 0.11 mu g/mL to 76 +/- 1.11 mu g/mL for HRBC membrane stabilization assay, respectively. The chloroform and ethanol extracts have exhibited good antiangiogenic property. Eventually, these results justified that the chloroform and ethanol extracts of T. subulata with great antioxidant, anti-inflammatory and antiangiogenesis potentials could be promising candidates for the development of a cost effective, potent anticancer drug with minimal side effects.