화학공학소재연구정보센터
Catalysis Letters, Vol.150, No.3, 874-880, 2020
Nickel-Catalyzed Esterification of Amides Under Mild Conditions
The use of ligands to adjust the catalytic activity of the catalyst for esterification of amides is challenge in organic chemistry. In this paper, Nickel(II)-NHC-catalyzed the esterification reaction between N,N-di-Boc amide and alcohols at room temperature have been demonstrated. The imidazolium salt bearing a hydroxyl functionalized side arm showed high effective catalytic activity in the activation of the amide N-C bond in air atmosphere. Graphic