Biochemical and Biophysical Research Communications, Vol.524, No.1, 70-76, 2020
Curcumin exerts anti-tumor effects on diffuse large B cell lymphoma via regulating PPAR gamma expression
Given the highly heterogeneity of diffuse large B cell lymphoma (DLBCL) and the diverse demands for proper treatment, many patients would relapse or show resistance to current therapeutic regimens, new treatment options are urgent to be explored. Curcumin harbored anti-tumor potential in various cancers, here, we investigated the possible effects and mechanism of curcumin on human DLBCL in vitro and in vivo, we found that curcumin inhibited cell viability in a concentration and time dependent manner, promoted cell apoptosis and arrested cell cycle at G2 phase, and these effects were mediated by PPAR gamma promotion and Akt/mTOR pathway inactivation. Furthermore, effects of curcumin on human DLBCL cells could be partly rescued by PPAR gamma antagonist GW9662, and enhanced by PPAR gamma agonist rosiglitazone. Taken together, our results demonstrated that curcumin inhibited the proliferation of DLBCL cells by upregulating the expression of PPAR gamma, and our results might provide novel therapeutic approaches and a potential target to DLBCL treatment. (C) 2020 Elsevier Inc. All rights reserved.