화학공학소재연구정보센터
Macromolecular Research, Vol.28, No.3, 211-220, March, 2020
Poly(ethylene glycol) Composite Hydrogels with Natural Zeolite as Filler for Controlled Delivery Applications
E-mail:,
In this study, composite hydrogels based on crosslinked polyethylene glycol diacrylate (PEGDA) and natural zeolite, with potential applications for the controlled release of phytoextracts, were synthesized by radical polymerization and characterized herein for the first time. The influence of various synthesis parameters, such as the use of distilled water or rose hip extract as reaction medium, or the percentage of the zeolite in the composite hydrogel upon the morphology, swelling kinetics and the rheological properties was investigated. By conducting polymerization of PEGDA in the rose hip extract, the crosslinking reaction yield was almost 100%, because of the chain transfer reactions of the polyphenols from the rose hip extract. Rose hip release tests were used to evaluate the release profiles of the natural bioactive substances from phytoextracts. The results showed that the hydrogel loaded with 3% zeolite displayed the lowest burst release and the slowest release rates of the extract.
  1. Peppas NA, Eds., Academic Press, New York, pp.100 2004.
  2. Hoare TR, Kohane DS, Polymer, 49(8), 1993 (2008)
  3. Won NI, Bok SH, Park JS, Na YH, Macromol. Res., 26(8), 717 (2018)
  4. Memic A, Alhadrami HA, Hussain MA, Aldhahri M, Nowaiser FA, Al-Hazmi F, Oklu R, Khademhosseini A, Biomed. Mater., 11, 014104 (2016)
  5. Motealleh A, Kehr NS, Adv. Healthc. Mater., 6, 160093 (2017)
  6. Krsko P, Libera M, Mater. Today, 8, 36 (2005)
  7. Cursaru B, Teodorescu M, Boscornea C, Stanescu PO, Stoleriu S, Mat. Sci. Eng. C-Mater., 33, 1307 (2013)
  8. Byun H, Hong B, Nam SY, Jung SY, Rhim JW, Lee SB, Moon GY, Macromol. Res., 16(3), 189 (2008)
  9. Biswas J, Kim H, Choe S, Kundu PP, Park YH, Lee DS, Macromol. Res., 11(5), 357 (2003)
  10. Song F, Li X, Wang Q, Liao L, Zhang C, J. Biomed. Nanotechnol., 11, 40 (2015)
  11. Gaharwar AK, Peppas NA, Khademhosseini A, Biotechnol. Bioeng., 111(3), 441 (2014)
  12. Huang Q, Liu S, Li K, Hussain I, Ya F, Fu G, J. Mater. Sci. Technol., 33, 821 (2017)
  13. Chang G, Li S, Huang F, Zhang X, Shen Y, Xie A, J. Mater. Sci. Technol., 32, 753 (2016)
  14. Pan Y, Shen Q, Pan C, Wang J, J. Mater. Sci. Technol., 29, 551 (2013)
  15. Adamczak A, Buchwald W, Zielinski Z, Mielcarek S, Acta. Biol. Cracov Bot., 54, 105 (2012)
  16. Roman I, Stanila A, Stanila S, Chem. Cent. J., 7, 73 (2013)
  17. Oprica L, Bucsa C, Zamfirache MM, Fascicula, 1, 1 (2016)
  18. Demir N, Yildiz O, Alpaslan M, Hayaloglu AA, LWT-Food Sci. Technol., 57, 126 (2014)
  19. Fattahi S, Jamei R, Sarghein SH, Iranian J. Plant. Physiol., 2, 523 (2012)
  20. Guimaraes R, Barros L, Duenas M, Carvalho AM, Queiroz MJRP, Santos-Buelga C, Ferreira ICFR, Food Chem., 141, 3721 (2013)
  21. Papuc C, Nicorescu V, Predescu NC, Petcu C, Bulletin UASMV, Vet. Med., 70, 114 (2013).
  22. Taghizadeh M, Rashidi AA, Taherian AA, Vakili Z, Sajadiyan SM, Gardashi M, Evid.-Based Comp. Alt., 21, 25 (2016)
  23. Tumbas VT, Canadanovic-Brunet JM, Cetojevic-Simin DD, Cetkovic GS, Ethilas SM, Gille L, J. Sci. Food Agric., 92, 1273 (2012)
  24. Mirzakhanian Z, Faghihi K, Barati A, Momeni HR, Int. J. Polym. Mater. Polym., 65, 779 (2016)
  25. Rashidzadeh A, Olad A, Reyhanitabar A, Polym. Bull., 72(10), 2667 (2015)
  26. Rashidzadeh A, Olad A, Salari D, Reyhanitabar A, J. Polym. Res., 21, 344 (2014)
  27. Sotoudeh S, Barati A, Davarnejad R, Farahani MA, Middle-East J. Sci. Res., 12, 392 (2012)
  28. Bokias G, Durand A, Hourdet D, Macromol. Chem. Phys., 19, 1387 (1998)
  29. Moad G, Solomon DH, The Chemistry of Radical Polymerization Second Fully revised edition, By ELSEVIER Ltd, pp.94 2005.
  30. David A, Teodorescu M, Stanescu PO, Stoleriu S, Mat. Plast., 51, 113 (2014)
  31. Ritger PL, Peppas NA, J. Control. Release, 5, 23 (1987)
  32. Korkuna O, Leboda R, kubiszewska-Zieba J, Vrublevska T, Gunko VM, Ryczkowski J, Microporous Mesoporous Mater., 87, 243 (2006)
  33. Tang Q, Wu J, Sun H, Fan S, Hu D, Lin J, Polym. Composite, 30, 1183 (2009)
  34. Ganguly S, Das NC, RSC Adv., 5, 18312 (2015)
  35. Bhattacharyya R, Ray SK, Chem. Eng. J., 260, 269 (2015)
  36. Gonzalez-Henriquez CM, Pizarro GC, Sarabia-Vallejos MA, Terraza CA, Lopez-Cabana ZE, Arab. J. Chem., doi: 10.1016/j.arabjc.2014.11.012 (2014).
  37. Chan MA, Obendorf KS, Fiber Polym., 15, 2032 (2014)
  38. Hou K, Li Y, Liu Y, Zhang RH, Hsiao BS, Zhu MF, Polymer, 123, 55 (2017)
  39. Kariminezhad H, Habibi M, Mirzababayi N, J. Photochem. Photobiol. B-Biol., 148, 107 (2015)
  40. Witte RP, Blake AJ, Palmer C, Kao WJ, J. Biomed. Mater. Res. A, 71, 508 (2004)
  41. Wong RSH, Dodou K, Polymers, 9, 286 (2017)
  42. Beutel T, J. Chem. Soc., 94, 985 (1998)
  43. Hedden RC, Saxena H, Cohen C, Macromolecules, 33(23), 8676 (2000)
  44. Thavasi V, Bettens RPA, Leong LP, J. Phys. Chem. A, 113(13), 3068 (2009)
  45. Barton SC, Bird RA, Russell KE, Can. J. Chem., 41, 2737 (1963)
  46. Padmavathi NC, Chatterji PR, Macromolecules, 29(6), 1976 (1996)
  47. Jiang Z, Cao X, Li Z, Guo L, J. Petrol. Explor. Prod. Technol., 6, 93 (2016)
  48. Beneduci A, Furia E, Russo N, Marino T, New J. Chem., 41, 5182 (2017)
  49. Zarzycki R, Modrzejewska Z, Nawrotek K, Ecol. Chem. Eng. S, 17, 117 (2010)
  50. Patel SK, Malone S, Cohen C, Gillmor JR, Colby RH, Macromolecules, 25, 5241 (1992)
  51. Panic VV, Velickovic SJ, Sep. Purif. Technol., 122, 384 (2014)
  52. Bhattarai N, Gunn J, Zhang M, Adv. Drug Deliver. Rev., 62, 83 (2010)