화학공학소재연구정보센터
Journal of the American Chemical Society, Vol.141, No.49, 19263-19268, 2019
Asymmetric Synthesis of Chiral Sulfoximines via the S-Arylation of Sulfinamides
Optically active sulfoximines are a promising substance in medicinal chemistry. However, a methodology for preparing chiral sulfoximines in a stereoselective manner has been underdeveloped. Here, we report an asymmetric synthesis of chiral sulfoximines having an aryl group by the newly developed sulfur-selective arylation of easily accessible chiral sulfinamides. The utility of the present method is demonstrated by the asymmetric synthesis of a key intermediate of a COX-2 inhibitor.