화학공학소재연구정보센터
Chemistry Letters, Vol.49, No.1, 103-106, 2020
Protein Nanoparticles Formed by Self-assembly of Human Serum Albumin with a Fatty Acid Arm
We report the preparation of spherical protein nanoparticles comprising self-assembled human serum albumin (HSA) with an N-(11-carboxyundecyl)succinimido (CU) arm in aqueous medium at pH 5.0. Molecular dynamics simulation implied that the alternate CU chain bindings and multiple hydrogen bonds contribute the interprotein interaction. Cross-linking of the protein components by glutaraldehyde stabilized the particle under physiological pH.