화학공학소재연구정보센터
Chemistry Letters, Vol.49, No.1, 1-9, 2020
Molecular Design of Polymer-based Carriers for Plasmid DNA Delivery In Vitro and In Vivo
In this review, recent studies on the molecular design of polymer-based carriers for plasmid DNA (pDNA) delivery in vitro and in vivo are described. From the viewpoint of in vitro pDNA delivery, molecular design for endosomal escape and nucleus localization is mainly reviewed. From the viewpoint of in vivo pDNA delivery, molecular design for biodistribution is mainly reviewed. Finally, molecular design for therapeutic medicine by the present desirable technology using pDNA delivery is reviewed.