화학공학소재연구정보센터
Journal of the American Chemical Society, Vol.141, No.44, 17512-17516, 2019
Symmetry-Breaking Charge Separation in a Nanoscale Terrylenediimide Guanine-Quadruplex Assembly
Guanine-quadruplex (G-quadruplex) assemblies provide a useful platform for studying the spatial, structural, and photophysical effects of intermolecular interactions. Coupling a single guanine moiety to terrylenediimide (TDI)-a chromophore with a large extended pi-surface-produces a structure (GTDI) that assembles in plate-like tetramers, with the potential of undergoing tunable pi-stacking. At high concentrations (3 x 10(-3) M), GTDI self-assembles into a nearly monodisperse G-quadruplex structure of 16 layers, with strong p-overlap between TDI moieties, observed by small- and wide-angle X-ray scattering. Transient absorption spectroscopy reveals that excitation of TDI in the G-quadruplex results in symmetry-breaking charge separation to form ion pairs within the structure, owing to the strong pi-overlap enforced by the hydrogen-bonding. These assemblies yield important insights into the interplay of noncovalent interactions in the assembly of ordered chromophoric arrays.