화학공학소재연구정보센터
Chemistry Letters, Vol.48, No.11, 1421-1432, 2019
Synthetic Methodology-driven Chemical Protein Modifications
The installation of novel and artificial functions to proteins through modifications of their chemical structure is an emerging research field covering chemistry, biology, and medicine. Because the reactions must proceed with high chemo- and regio-selectivity under mild conditions in aqueous solvents, developing chemical methods for precise protein modifications affording homogenous products is a great challenge in organic synthesis. Here we review selected recent examples of synthetically inspiring chemical protein modifications. The chemistry discussed here will lead to novel methodologies for the efficient synthesis of broad range of organic molecules.