화학공학소재연구정보센터
Chemistry Letters, Vol.48, No.8, 768-770, 2019
Facile Construction of an alpha-(1-Cyclopentenyl)ketone Core by Ruthenium-catalyzed Hydrative Cyclization of 1,6-Allenyne: Total Synthesis of (+)-Myomontanone
Ruthenium-catalyzed hydrative cyclization of 1,6-allenyne in the presence of H2O was demonstrated. The reaction proceeded via nucleophilic attack of H2O to a ruthenacyclopentene intermediate, giving an alpha-(1-cyclopentenyl)ketone derivative under mild conditions. In addition, the total synthesis of (+)-myomontanone was achieved by using ruthenium-catalyzed hydrative cyclization of 1,6-allenye as a key step.