화학공학소재연구정보센터
Biochemical and Biophysical Research Communications, Vol.514, No.3, 919-925, 2019
Protective effects of SND1 in retinal photoreceptor cell damage induced by ionizing radiation
Staphylococcal nuclease and tudor domain containing 1 (SND1) has multiple functions in a variety of cellular processes. Here, we assessed the effects of SND1 in cellular DNA damage after ionizing radiation (IR). Knocking down SND1 in the mouse-derived photoreceptor 661 W cell line markedly inhibited cell proliferation and increased apoptosis after IR treatment. After DNA damage, SND1 induced Ataxia telangiectasia mutated kinase (ATM) signaling to launch DNA repair. Defects of SND1 were associated with missing response to DNA damage signal to cell cycle checkpoints or DNA repair. The current findings reveal SND1 as a new regulatory factor in DNA damage response. (C) 2019 The Authors. Published by Elsevier Inc.