화학공학소재연구정보센터
Journal of Industrial and Engineering Chemistry, Vol.77, 408-415, September, 2019
Improved magnetic relaxivity via hierarchical surface structure of dysprosium-engineered superparamagnetic iron oxide nanoparticles in ultra-high magnetic field
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To date, it is unknown whether the combination of Dy ions and superparamagnetic iron oxide (SPIO; Fe3O4) NPs can offer improved performance in UHF-MRI. In this work, we provide a paradigm of hierarchical surface-structured (His) DyxFe3-xO4 NPs as T2 MRI nanoprobes at UHF (9.4 T). We found that His-DyxFe3-xO4 NPs (x = 0.2) possess a higher transverse relaxivity than unmodified His-SPIO NPs and a significantly enhanced r2/r1 ratio (up to~10.4 times higher) than those of reported Dy-based T2 MRI probes at 9.4 T. Furthermore, we demonstrate the effects of surface design of DyxFe3-xO4 NPs on their magnetic relaxivity and in vivo performance at UHF. The markedly enhanced r2/r1 of His-DyxFe3-xO4 NPs (x = 0.2) at 9.4 T is mainly attributed to decreased r1 relaxivity owing to the surface design and the possible disturbance of the Dy-Fe superexchange interaction. This work could provide an insightful strategy for the design of lanthanide-doped magnetic nanosystems as potential T2 MRI nanoprobes in UHF.
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