화학공학소재연구정보센터
Journal of Materials Science, Vol.54, No.13, 9729-9744, 2019
Bicompartmental microparticles loaded with antibacterial agents for prolonging food shelf life
The aim of this work was to fabricate disk-shaped bicompartmental microparticles loaded with antibacterial agent (benzoic acid) using electrohydrodynamic co-jetting technique for prolonging food shelf life. The particles were composed of a semi-crystalline polymer (polylactide, PLA) and an amorphous polymer (poly(lactide-co-glycolide), 50:50, PLGA) as individual compartment to encapsulate antibacterial active in either of them with a high active loading (30wt%) and encapsulation efficiency (>94%), and the purpose was to release the active at a desired rate depending on its location and pH of the environment. In order to utilize their controlled release characteristics (100% release over 60days at neutral pH), the antibacterial activity of the particles was evaluated against both gram-negative and gram-positive bacteria over a period of 30days at 37 degrees C and similar to 100% bacterial growth reduction was observed. Their prolonged antibacterial activity was also demonstrated on a food model (watermelon juice) over the stipulated time period.