Journal of Chemical Thermodynamics, Vol.132, 54-61, 2019
The dissolution behavior and apparent thermodynamic analysis of temozolomide in pure and mixed solvents
In commonly used solvents, the dissolving capacity of temozolomide is limited. This work is to research the dissolution behavior in different polarity ranges. The solubility of temozolomide in methanol, ethanol, n-propanol, isopropanol, acetone, acetonitrile, N,N-dimethylformamide (DMF), ethyl acetate, dimethyl sulfoxide (DMSO), 1,4-dioxane and mixture of (DMF + ethanol) was experimentally determined at T= 293.15-333.15 K. The modified Apelblat equation, lambda h equation, Jouyban-Acree model and CNIBS/R-K model are applied to correlate the solubility. All the values of RAD and RMSD are no more than 3.43 x 10(2) and 2.86 x 10(4), respectively. Apparent thermodynamic analysis indicate that the dissolution is an endothermic, spontaneous and entropy driven process. More importantly, the change of temperature and the addition of co-solvent (DMF) can make the operation of crystallization purification more controllable. (C) 2018 Published by Elsevier Ltd.