화학공학소재연구정보센터
Applied Surface Science, Vol.475, 934-941, 2019
Surface modification of AO-PAN@OHec nanofiber membranes with amino acid for antifouling and hemocompatible properties
By blending the modified laponite (OHec) and polyacrylonitrile (PAN), we prepared polyacrylonitrile nanofiber membranes (PAN@OHec) using the electrospinning technique. Then, the amidoxime modification was carried on using the hydroxylamine hydrochloride, yielding -NH2 contained amidoximated polyacrylonitrile nanofiber membranes (AO-PAN@OHec). Amino acids were grafted onto AO-PAN@OHec by a hydrothermal method to prepare materials with a good hemocompatibility. The morphology, structure, wettability, and chargeability of the modified Lys-PAN@OHec nanofiber membranes were characterized by Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR), Energy dispersive X-ray (EDX), X-ray photoelectron spectroscopy (XPS), WCA and Solid zeta potential measurements. We investigated the anti-protein contamination ability of the modified PAN nanofiber membranes. Hemocompatibility of the modified PAN nanofiber membranes were evaluated by the adhesion property of the platelet and erythrocyte. As a result, the hydrophilicity of the modified PAN nanofiber membranes were significantly improved. The protein adsorption was decreased. Besides, the modified membranes were proved to suppress the adhesion of platelet and erythrocyte compared with original PAN membranes.