Journal of Supercritical Fluids, Vol.140, 62-71, 2018
Supercritical CO2 extraction of cinnamaldehyde and eugenol from cinnamon bark: Optimization of operating conditions via response surface methodology
Cinnamaldehyde and eugenol were extracted by supercritical carbon dioxide. The results of cinnamaldehyde and eugenol recovery indicated that the data sufficiently fitted into a second-order polynomial model. The R-2 and adjusted R-2 turned out to be 95.26% and 91.11% for cinnamaldehyde and 97.93% and 96.12% for eugenol. The response surface methodology (RSM) modelling predicts the optimum operating conditions for cinnamaldehyde to be the pressure of 2.3 M Pa, temperature of 68.2 degrees C, flow rate of 1.8 ml/min and dynamic extraction time of 95.7 min with maximum recovery of 54.79 w/w%. The RSM modelling also predicts the eugenol maximum recovery of 38.42 w/w%, which was obtained at optimal operating conditions of 42.04 degrees C, 2.7 MPa, 2.3 ml/min and 118 min dynamic extraction time. Accuracy of modelling optimal cinnamaldehyde and eugenol recoveries were validated using triplicate experiments providing the average extraction recoveries of 54 +/- 1% and 38 +/- 1.5%, respectively.