화학공학소재연구정보센터
Biochemical and Biophysical Research Communications, Vol.504, No.4, 698-703, 2018
Distinct modulation of group I ribozyme activity among stereoisomers of a synthetic pentamine with structural constraints
Among cationic molecules that can modulate ribozyme activities, polyamines act as both activator and inhibitor of ribozyme reactions partly due to their structural flexibility. Restriction of structural flexibility of polyamines may allow them to emphasize particular modulation effects. We examined eight stereo isomers of a synthetic pentamine bearing three cyclopentane rings. In the reaction of a structurally unstable group I ribozyme, three stereoisomers exhibited distinct effects as inhibitor, an additive with a neutral effect, and also as an activator. (C) 2018 Elsevier Inc. All rights reserved.