화학공학소재연구정보센터
Particulate Science and Technology, Vol.36, No.6, 666-671, 2018
Continuous nanoparticles production through a combination of a micro electro mechanical system and an electromagnetic resonator cavity
In the present work, a reliable, rapid, and controllable method is developed for the continuous generation of pharmaceutical curcumin and loratadine nanoparticles (NPs). Micro droplets of curcumin and loratadine were generated by atomization of their corresponding solutions by a combination of a micro electro mechanical system and an electromagnetic resonator cavity. After evaporation of the solvent of micro droplets by electromagnetic waves, the NPs were collected by a polytetrafluoroethylene (PTFE) filter. NPs were characterized by scanning electron microscopy. Results showed that this method can be an effective way to produce amorphous NPs with narrow particle size distribution, where particle size can be easily controlled by solution concentration. Particles size varies from 152 to 446nm and from 116 to 719nm for loratadine and curcumin, respectively.