화학공학소재연구정보센터
Biochemical and Biophysical Research Communications, Vol.499, No.3, 454-458, 2018
Soy undecapeptide induces Drosophila hind leg grooming via dopamine receptor
beta-Conglycinin a subunit (323-333) [beta CG alpha(323-333)] is an exogenous neuromodulating undecapeptide found from enzymatic digest of P-conglycinin, a soy major storage protein by mice behavior tests. We investigated effect of beta CG alpha(323-333) on Drosophila behavior. Oral administration of beta CG alpha(323-333) in Drosophila increased hind leg grooming, which may act through specific sets of neurons. It was reported that dopamine receptor (DopR) meditates hind leg grooming, and we tested involvement of DopR in beta CG alpha(323-333)-induced hind leg grooming by using DopR knockout flies. In the wild type but not in the DopR-knockout flies, beta CG alpha(323-333) increased hind leg grooming. These results suggest that beta CG alpha(323333) induces hind leg grooming via activating the DopR. This is the first report showing that exogenously administered peptide changes fly behaviors. (C) 2018 Elsevier Inc. All rights reserved.