화학공학소재연구정보센터
Macromolecular Research, Vol.26, No.2, 128-138, February, 2018
Enhanced Tissue Compatibility of Polyetheretherketone Disks by Dopamine-Mediated Protein Immobilization
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Polyetheretherketone (PEEK) disks with hydrophilic and bioactive surface properties were prepared by covalent immobilization of collagen (Col) or insulin (In) on poly-dopamine (D)-coated PEEK samples using WSC (water soluble carbodiimide) as an activating agent. The poly-dopamine on the PEEK disk was coated by carrying out self-assembled polymerization of the dopamine neurotransmitter in a basic medium at pH 8.5. The poly-dopamine coating of the PEEK surface facilitated the deposition of a uniform layer of aligned molecules of collagen, which increased the bioactivity of the PEEK surfaces allowing for adhesion, proliferation, and osteogenic differentiation of MC3T3-E1 cells in a minimum essential medium in the presence of 5% CO2 at 37 °C. The collagen-modified PEEK surface had higher bioactivity for MC3T3-E1 cells, compared to the self-assembled poly-dopamine coated PEEK surface or pristine PEEK alone. Alkaline phosphatase, von Kossa, and Alizarin red staining of MC3T3-E1 cells cultured on a collagen-modified PEEK surface, were all found to be increased compared to staining of cells cultured on other PEEK surfaces. The self-assembled polymerization of dopamine on a PEEK surface was found to be useful for the immobilization of proteins such as collagen and insulin. Thus, collagen-and insulinimmobilized PEEK provide an opportunity to enhance the bioactivity of the PEEK samples allowing for better cells adhesion and tissue integration for potential use in tissue implants.
  1. Mano JF, Sousa RA, Boesel LF, Neves NM, Reis RL, Compos. Sci. Technol., 64, 789 (2004)
  2. Kurtz SM, Devine JN, Biomaterials, 28, 4845 (2007)
  3. Jiya T, Smit T, Deddens J, Spine, 34, 233 (2009)
  4. Park HW, Lee JK, Moon SJ, Seo SK, Lee JH, Kim SH, Spine, 34, E591 (2009)
  5. Toth JM, Wang M, Estes BT, Scifert JL, Seim HB, Biomaterials, 27, 324 (2006)
  6. Rivard CH, Rhalmi S, Coillard C, J. Biomed. Mater. Res., 62, 488 (2002)
  7. Jarman-Smith M, Med. Device Technol., 19, 12 (2008)
  8. Williams D, Med. Device Technol., 19, 10 (2008)
  9. Godara A, Raabe D, Green S, Acta Biomater., 3, 209 (2007)
  10. Williams DF, McNamara A, Turner RM, J. Mater. Sci. Lett., 6, 188 (1987)
  11. Nieminen T, Kallela I, Wuolijoki E, Kainulainen H, Hiidenheimo I, Rantala I, J. Biomed. Mater. Res. A, 84, 377 (2008)
  12. Wang H, Xu M, Zhang W, Kwok DT, Jiang J, Wu Z, Chu PK, Biomaterials, 31, 8181 (2010)
  13. Katzer A, Marquardt H, Westendorf J, Wening JV, Foerster GV, Biomaterials, 23, 1749 (2002)
  14. Nickels L, Metal Powder Report, 67, 12 (2012)
  15. Briem D, Strametz S, Schroder K, Meenen NM, Lehmann W, Linhart W, Ohl A, Rueger JM, J. Mater. Sci. Mater. Med., 16, 671 (2005)
  16. Ha SW, Kirch M, Birchler F, Eckert KL, Mayer J, Wintermantel E, Sittig C, Pfund-Klingenfuss I, Textor M, Spencer ND, Guecheva M, Vonmont H, J. Mater. Sci. -Mater. Med., 8, 683 (1997)
  17. Wu GM, Hsiao WD, Kung SF, Surf. Coat. Technol., 203, 2755 (2009)
  18. Michael R, Jack OJ, Dongdong F, Mohamed-Nur A, Michael PH, Alex M, Faleh Mlynarek T, Simon DT, J. Biomater. Appl., 31, 132 (2016)
  19. Davood A, Nida I, Maliheh S, Izman S, Mohammed R, Abdul K, Tunku K, Int. J. Biomater., 2016, 12 (2016)
  20. Poulsson AHC, Richards RG, in PEEK Biomaterials Handbook, S. M. Kurtz, Ed., William Andrew, Oxford, 2012, Chap. 10, pp 145-161.
  21. Hsi-Kai T, Meng-Hui C, Yi-Wen H, Chi-Jen C, Ju-Liang H, BioMed Res. Int., 2015, 9 (2015)
  22. Tsou HK, Hsieh PY, Chi MH, Chung CJ, He JL, J. Biomed. Mater. Res. Part A, 100, 2787 (2012)
  23. Han CM, Lee EJ, Kim HE, Koh YH, Kim KN, Ha Y, Kuh SU, Biomaterials, 31, 3465 (2010)
  24. Li LH, Kong YM, Kim HW, Kim YW, Kim HE, Heo SJ, Koak JY, Biomaterials, 25, 2867 (2004)
  25. Svetina M, Ciacchi LC, Sbaizero O, Meriani S, De Vita A, Acta Mater., 49, 2169 (2001)
  26. Wu X, Liu X, Wei J, Ma J, Deng F, Wei S, Int. J. Nanomed., 7, 1215 (2012)
  27. Pino M, Stingelin N, Tanner KE, Acta Biomater., 4, 1827 (2008)
  28. Tsou HK, Hsieh PY, Chung CJ, Tang CH, Shyr TW, He JL, Surf. Coat. Technol., 204, 1121 (2009)
  29. Landy BC, VanGordon SB, McFetridge PS, Sikavitsas VI, Jarman-Smith M, J. Appl. Biomater. Funct. Mater., 11, 35 (2013)
  30. Almasi D, Izman S, Sadeghi M, Iqbal N, Roozbahani F, Krishnamurithy G, Kamarul T, Kadir MRA, Int. J. Biomater., 2015, 475435 (2015)
  31. Marchandbrynaert J, Pantano G, Noiset O, Polymer, 38(6), 1387 (1997)
  32. Noiset O, Schneider YJ, Marchand-Brynaert J, J Biomater. Sci. Polym. Ed., 10, 657 (1999)
  33. Noiset O, Schneider YJ, Marchand-Brynaert J, J. Biomater. Sci. Polym. Ed., 11, 767 (2000)
  34. Ya-Wei D, Li-Nan Z, Xin Y, He-Min N, Zeng-Tao H, Teng-Hui Z, Guo-Ping Y, Peng S, Front. Mater. Sci., 9, 38 (2015)
  35. Yang K, Lee JS, Kim J, Lee YB, Shin H, Um SH, Kim JB, Park KI, Lee H, Cho SW, Biomaterials, 33, 6952 (2012)
  36. Chuah YJ, Koh YT, Lim K, Menon NV, Wu Y, Kang Y, Sci. Rep., 5, 18162 (2015)
  37. Ge LP, Li QT, Huang Y, Yang SQ, Ouyang J, Bu SS, Zhong W, Liu ZH, Xing MMQ, J. Mater. Chem. B, 2, 6917 (2014)
  38. Zhou P, Wu F, Zhou T, Cai X, Zhang S, Zhang X, Li Q, Li Y, Zheng Y, Wang M, Lan F, Pan G, Pei D, Wei S, Biomaterials, 87, 1 (2016)
  39. Lin CC, Fu SJ, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 58, 254 (2016)
  40. Kao CT, Lin CC, Chen YW, Yeh CH, Fang HY, Shie MY, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 56, 165 (2015)
  41. Erndt-Marino JD, Munoz-Pinto DJ, Samavedi S, Jimenez-Vergara AC, Diaz-Rodriguez P, Woodard L, Zhang D, Grunlan MA, Hahn MS, ACS Biomater. Sci. Eng., 1, 1220 (2015)
  42. Ye Q, Zhou F, Liu W, Chem. Soc. Rev., 40, 4244 (2011)
  43. Lee H, Dellatore SM, Miller WM, Messersmith PB, Science, 318, 426 (2007)
  44. Benhabbour SR, Sheardown H, Adronov A, Biomaterials, 29, 4177 (2008)
  45. Hopper AP, Dugan JM, Gill AA, Fox OJL, May PW, Haycock J, Claeyssens F, Biomed. Mater., 9, 045009 (2014)
  46. Arima Y, Iwata H, Biomaterials, 28, 3074 (2007)
  47. Levato R, Planell JA, Mateos-Timoneda MA, Engel E, Acta Biomater., 18, 59 (2015)
  48. Boccafoschi F, Fusaro L, Mosca C, Bosetti M, Chevallier P, Mantovani D, Cannas MJ, J. Biomed. Mater. Res. A, 100, 2373 (2012)
  49. Chen FM, Chen R, Wang XJ, Sun HH, Wu ZF, Biomaterials, 30, 215 (2009)
  50. Lee H, Rho J, Messersmith PB, Adv. Mater., 20, 1 (2008)
  51. Lee H, Lee Y, Statz AR, Rho J, Park TG, Messersmith PB, Adv. Mater., 20(9), 1619 (2008)
  52. Lee H, Dellatore SM, Miller WM, Messersmith PB, Science, 318, 426 (2007)
  53. Dalsin JL, Hu BH, Lee BP, Messersmith PB, J. Am. Chem. Soc., 125(14), 4253 (2003)
  54. Yang Z, Tu Q, Zhu Y, Luo R, Li X, Xie Y, Maitz MF, Wang J, Huang N, Adv. Healthc. Mater., 1, 548 (2012)
  55. Jeong KJ, Wang L, Stefanescu CF, Lawlor MW, Polat J, Dohlman CH, Langer RS, Kohane DS, Soft Matter, 7, 8305 (2011)
  56. Jal PK, Patel S, Mishra BK, Talanta, 62, 1002 (2004)
  57. Nanci A, Wuest JD, Peru L, Brunet P, Sharma V, Zalzal S, McKee MD, J. Biomed. Mater. Res., 40, 324 (1998)
  58. Cen L, Liu W, Cui L, Zhang W, Cao Y, Pediatr. Res., 63, 492 (2008)
  59. Abraham LC, Zuena E, Perez-Ramirez B, Kaplan DL, J. Biomed. Mater. Res. B: Appl. Biomater., 87, 264 (2008)
  60. Van Den Dolder J, Jansen JA, J. Biomed. Mater. Res. A, 83, 712 (2007)
  61. Yu X, Xia X, Wang L, Peng F, Jiang X, Huang J, Rowe D, Wei MJ, Mater. Chem., 22, 9721 (2012)
  62. Xia Z, Yu X, Jiang X, Brody HD, Rowe DW, Wei M, Acta Biomater., 9, 7308 (2013)
  63. Muller R, Abke J, Schnell E, Macionczyk F, Gbureck U, Mehrl R, Ruszczak Z, Kujat R, Englert C, Nerlich M, Angele P, Biomaterials, 26, 6962 (2005)
  64. Kasemset S, Lee A, Miller DJ, Freeman BD, Sharma MM, J. Membr. Sci., 425, 208 (2013)
  65. Shin YM, Jun I, Lim YM, Rhim T, Shin H, Macromol. Mater. Eng., 298, 555 (2013)
  66. VandeVondele S, Voros J, Hubbell JA, Biotechnol. Bioeng., 82(7), 784 (2003)
  67. Jo S, Kang SM, Park SA, Kim WD, Kwak J, Lee H, Macromol. Biosci., 13, 1389 (2013)
  68. Sonseca A, Peponi L, Sahuquillo O, Kenny JM, Gimenez E, Polym. Degrad. Stabil., 97, 2052 (2012)
  69. Lan-Xin L, Xiao-Feng Z, Yan-Yan W, Lazarus O, Xi X, Zan-Li J, Zhong-Dang X, Ning-Ping H, Appl. Mater. Interface., 5, 319 (2013)
  70. Sabokbar A, Millett PJ, Myer B, Rushton N, Bone Min., 27, 57 (1994)
  71. Neha D, Heidi LH, Vassilios IS, John AJ, Antonios GM, Biomaterials, 26, 971 (2005)