Journal of the Electrochemical Society, Vol.164, No.6, B314-B320, 2017
Electrochemical Characterization of a Carbon Ceramic Electrode Modified with a Ru(II) Arene Complex and Its Application as Voltammetric Sensor for Paracetamol
An arene-ruthenium (II) complex - [Ru(eta(6)-p-cymene)(ampy)Cl]PF6, where ampy is 2-(aminomethyl) pyridine -was synthesized and used in the construction of a modified carbon ceramic electrode (Ru-CCE) for determining paracetamol (PCT) by square wave voltammetry (SWV). The modified electrode, constructed by sol-gel methods, provides a considerable enhancement of PCT oxidation. Under the optimized working conditions, the peak current is linear to the PCT concentration in the ranges of 1.99 x 10(-6) - 3.10 x 10(-5) mol L-1 with a detection limit of 5.83 x 10(-7) mol L-1. The Ru-CCE showed good repeatability and reproducibility (RSD < 4%), long-term stability (> 12 months). Lastly, the proposed sensor was used for the determination of PCT in pharmaceutical formulations, offering a promising tool for quality control. (C) 2017 The Electrochemical Society. All rights reserved.