화학공학소재연구정보센터
Journal of the American Chemical Society, Vol.139, No.22, 7432-7435, 2017
Iodide-Selective Synthetic Ion Channels Based on Shape-Persistent Organic Cages
We report here a synthetic ion channel developed from a shape-persistent porphyrin-based covalent organic cage. The cage was synthesized by employing a synthetically economical dynamic covalent chemistry (DCC) approach. The organic cage selectively transports biologically relevant iodide ions over other inorganic anions by a dehydration-driven, channel mechanism as evidenced by vesicle-based fluorescence assays and planar lipid bilayer-based single channel recordings. Furthermore, the organic cage appears to facilitate iodide transport across the membrane of a hying cell, suggesting that the cage could be useful as a biological tool that may replace defective iodide channels in living systems: