화학공학소재연구정보센터
Chemistry Letters, Vol.46, No.6, 811-813, 2017
Bio-inspired Domino Reduction of Nitroarenes by Acrolein-Amine Conjugates in One-pot Operation
Biologically relevant amines react with acrolein to provide 3-formyl-3,4-dehydropiperidine (FDP) as the oxidative stress product, which has reduction potential via hydrogen transfer. This biogenic process was applied to the domino reduction of electron-deficient nitroarenes in one-pot operation, by simply mixing primary amine, acrolein, nitroarene, and calcium chloride. The reaction can be performed in a gram-scale without the use of hazardous metals.