화학공학소재연구정보센터
Polymer(Korea), Vol.41, No.2, 318-323, March, 2017
Methylcellulose 조성 온도 감응성 졸-젤 유착방지제
Adhesion Barrier of Methylcellulose Based Thermo-Responsive Sol-Gel
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초록
유착방지막을 제조하기 위해 methylcellulose(MC)와 xanthan gum(XT) 조성의 온도 감응성 졸-젤을 제조하였다. MC/XT 졸(sol)은 사람의 신체온도(37 °C)에서 1분 안에 젤화(gelation)가 일어나는 것을 보였다. Rat에 온도 감응성 졸-젤을 주입하여 생체적합성 및 생체분해성을 확인하였다. 또한 온도 감응성 졸-젤이 장기 및 조직의 유착방지에 효과가 높은 것을 관찰하였다. 그 결과 MC/XT 졸-젤은 조직 유착방지막의 좋은 후보 물질임을 확인하였다.
Thermo-responsive sol-gel was prepared from methylcellulose (MC) and xanthan gum (XT) for adhesion barrier. The prepared MC/XT sol-gel showed transition temperature and gelation around body temperature (37 °C) within 1 min. In vivo biocompatibility and biodegradability of the MC/XT sol-gel were validated by implantation of the gel in rats. Also, the MC/XT sol-gel was highly effective for the prevention of tissue and organ adhesion. Therefore, the MC/XT sol-gel can be a good candidate material as a tissue adhesion barrier.
  1. Li Y, Rodrigues J, Tomas H, Chem. Soc. Rev., 41, 2193 (2012)
  2. Gutowska A, Jeong B, Jasionowski M, Anatom. Record., 263, 342 (2001)
  3. Namgung R, Kim WJ, Biomater. Res., 14, 86 (2010)
  4. Klouda L, Mikos AG, Eur. J. Pharm. Biopharm., 68, 34 (2008)
  5. Park JK, Nah JW, Choi C, Polym. Korea, 39(3), 480 (2015)
  6. You HS, Cho MO, Cho IS, Li Z, Kim NH, Jang MK, Kang SW, Huh KM, Polym. Korea, 40(2), 328 (2016)
  7. Li L, Macromolecules, 35(15), 5990 (2002)
  8. Park JK, Lee KJ, Son DH, Choi C, Jang MK, Nah JW, J. Chitin Chitosan, 16, 45 (2011)
  9. Kim JK, Won YW, Lim KS, Kim YH, Pharm. Res., 29, 525 (2012)
  10. Kobayashi K, Huang CI, Lodge TP, Macromolecules, 32(21), 7070 (1999)
  11. Sarkar N, Walker LC, Carbohydr. Polym., 27, 177 (1995)
  12. Li L, Shan H, Yue CY, Lam YC, Tam KC, Hu X, Langmuir, 18(20), 7291 (2002)
  13. Elham K, Fariba G, Mohsen T, Maryam S, Iran Polym. J., 22, 785 (2013)
  14. Liu Z, Yao P, Carbohydr. Polym., 132, 490 (2015)
  15. Oh AG, Biomater. Res., 17, 138 (2013)
  16. Kim J, Cho EB, Lee CM, Lee KY, Polym. Korea, 40(2), 306 (2016)