화학공학소재연구정보센터
Biotechnology Letters, Vol.39, No.1, 33-38, 2017
MicroRNA-1284 inhibits proliferation and induces apoptosis in SGC-7901 human gastric cancer cells
To explore the functional effects of miR-1284 on gastric cancer cells. Overexpression of miR-1284 significantly reduced SGC-7901 cell proliferation, but improved apoptosis. However, miR-1284 suppression displayed the inversed impacts. Furthermore, the protein levels of p27, Bax, procaspase-3 and active caspase-3 were up-regulated by miR-1284 overexpression, but were down-regulated by miR-1284 suppression. The level of Bcl-2 was down-regulated by miR-1284 overexpression, while it was up-regulated by miR-1284 suppression. The level of p21 was unaffected. These results suggest that miR-1284 overexpression might be a suppressor for gastric cancer via controlling of cell proliferation and apoptosis.