화학공학소재연구정보센터
Biochemical and Biophysical Research Communications, Vol.480, No.4, 570-573, 2016
ZIP restores estrogen receptor expression and response to Tamoxifen in estrogen receptor negative tumors
As a component of NURD histone deacetylase complex, ZIP serves as a tumor suppressor gene in the development of breast tumors. However, whether it takes part in chemotherapy resistance remains poorly defined. In the present study, we reported that ZIP enhanced the response to SERM chemotherapy in ER-negative cells. Overexpression of ZIP suppressed EGFR expression level and restored ERalpha protein level in cells resistant to Tamoxifen. In vivo data confirmed those in vitro findings. (C) 2016 Elsevier Inc. All rights reserved.