화학공학소재연구정보센터
Journal of the American Chemical Society, Vol.138, No.35, 11077-11080, 2016
A Highly Efficient Single-Chain Metal Organic Nanoparticle Catalyst for Alkyne-Azide "Click" Reactions in Water and in Cells
We show that copper-containing metal organic nanoparticles (MONPs) are readily synthesized via Cu(II)-mediated intramolecular cross-linking of aspartate-containing polyolefins in water. In situ reduction with sodium ascorbate yields Cu(I)-containing MONPs that serve as highly efficient supramolecular catalysts for alkyne azide "click chemistry" reactions, yielding the desired 1,4-adducts at low parts per million catalyst levels. The nanoparticles have low toxicity and low metal loadings, making them convenient, green catalysts for alkyne azide "click" reactions in water. The Cu-MONPs enter cells and perform efficient, biocompatible click chemistry, thus acting as intracellular nanoscale molecular synthesizers.