Canadian Journal of Chemical Engineering, Vol.94, No.4, 733-737, 2016
Drop forming as a basis for scaling up of the in situ coating process
Cutting the costs of tablet manufacture is one of the many advantages melt crystallization offers as a technology for producing pharmaceutical coated tablets, compared to conventional tableting procedure. Other advantages include the lower number of steps needed for production, which increases productivity; the lower energy and workforce requirements; and the decreased need for stricter post-production quality control measures while maintaining quality. The scientific term for maintaining quality is ensuring the reproducibility of experimental results. The main focus of this study is to scale up the drop-forming process of coating, in this case of ibuprofen tablets using Lutrol. The main emphasis therefore focuses on transferring the respective optimized conditions that work for the respective system onto the industrial device. This results in the production of tablets with consistent quality in terms of geometry and coat purity. This goes in hand with the extensive modifications applied to the device for the purpose of process scale-up. The final outcome is represented in a scaled-up production of the coated pharmaceutical tablets through the process of melt crystallization, the reproducibility of which as a tablet manufacturing method is also proven.