International Journal of Molecular Sciences, Vol.16, No.4, 8070-8101, 2015
Iron Oxide Nanoparticles for Magnetically-Guided and Magnetically-Responsive Drug Delivery
In this review, we discuss the recent advances in and problems with the use of magnetically-guided and magnetically-responsive nanoparticles in drug delivery and magnetofection. In magnetically-guided nanoparticles, a constant external magnetic field is used to transport magnetic nanoparticles loaded with drugs to a specific site within the body or to increase the transfection capacity. Magnetofection is the delivery of nucleic acids under the influence of a magnetic field acting on nucleic acid vectors that are associated with magnetic nanoparticles. In magnetically-responsive nanoparticles, magnetic nanoparticles are encapsulated or embedded in a larger colloidal structure that carries a drug. In this last case, an alternating magnetic field can modify the structure of the colloid, thereby providing spatial and temporal control over drug release.
Keywords:magnetic nanoparticles;magnetoliposomes;liposomes;gels;nanotechnology;controlled release;chemotherapy