화학공학소재연구정보센터
Chemistry Letters, Vol.44, No.4, 425-427, 2015
Synthesis and G-Quadruplex-binding Properties of Cationic Platinum(II) Terpyridine Complexes Containing sigma-Alkynyl Auxiliaries
The cationic alkynylplatinum(II) terpyridMe complexes show high affinity (K-a > 10(7) M-1) and reasonable selectivity for telomeric and c-myc G-quadruplexes over duplex DNA. In the absence of alkali cations, these Pt(II) complexes can promote the formation and stabilization of G-quadruplexes. The cytotoxicity of complexes 2 and 3 against the A549 cancer cell line is ca. 25-fold and 35-fold higher than that of cisplatin, respectively.