화학공학소재연구정보센터
Biochemical and Biophysical Research Communications, Vol.461, No.2, 366-371, 2015
PML suppresses IL-6-induced STAT3 activation by interfering with STAT3 and HDAC3 interaction
The promyelocytic leukemia protein PML acts as a tumor suppressor by forming transcription-regulatory complexes with a variety of repressor proteins. In the present study, we found that endogenous PML suppresses interleukin (IL)-6-induced gene expression as well as phosphorylation and transcriptional activation of STAT3 in hepatoma cells. We also found that PML-mediated suppression of IL-6-induced STAT3 activation by disrupting interactions between STAT3 and HDAC3. These results indicate that PML modulates IL-6-induced STAT3 activation and hepatoma cell growth by interacting with HDAC3. (C) 2015 Elsevier Inc. All rights reserved.