화학공학소재연구정보센터
Biochemical and Biophysical Research Communications, Vol.458, No.2, 221-226, 2015
Dicarbonyl stress in cell and tissue dysfunction contributing to ageing and disease
Dicarbonyl stress is the abnormal accumulation of dicarbonyl metabolites leading to increased protein and DNA modification contributing to cell and tissue dysfunction in ageing and disease. Enzymes metabolising dicarbonyls, glyoxalase 1 and aldoketo reductases, provide an efficient and stress-response enzyme defence against dicarbonyl stress. Dicarbonyl stress is produced by increased formation and/or decreased metabolism of dicarbonyl metabolites, and by exposure to exogenous dicarbonyls. It contributes to ageing, disease and activity of cytototoxic chemotherapeutic agents. (C) 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license