Advanced Materials, Vol.28, No.12, 2417-2420, 2016
Photocrosslinking of Silk Fibroin Using Riboflavin for Ocular Prostheses
A novel method to photocrosslink silk fibroin protein is reported, using riboflavin (vitamin B2) as a photoinitiator and the mechanism of crosslinking is determined. Exposure of riboflavin-doped liquid silk solution to light results in the formation of a transparent, elastic hydrogel. Several applications for this new material are investigated including corneal reshaping to restore visual acuity and photolithography. [GRAPHICS] .