Molecular Crystals and Liquid Crystals, Vol.388, 581-585, 2002
Different tissue reactions to activated carbon fivers - Pathological and immunological findings after subcutaneous implantation
We have shown here effects on biological affinity of activated carbon fivers (ACFs) comparing with that of asbestos. ACFs and asbestos have been implanted into subcutaneous tissues of mice for 6 months. Histological and immunological investigations have been performed. As results, tissue samples implanted asbestos showed a severe inflammatory reaction and formation of abscess-like mass in their implanted tissues. Changes of CD4+/CD8+ were markedly occurred in the asbestos implanted group. Between ACFs, A-20 showed better tissue affinity histologically and immunologically in indicating that a micro-pore size with a surface of those composted materials may be important as a factor of biological responses to those materials.