화학공학소재연구정보센터
Applied Chemistry, Vol.3, No.2, 57-60, October, 1999
Blood Compatibility of Heparinized AAc, HEMA, and PEGMA-grafted Cellulose Film by Radiation Grafting
To improve surface blood compatibility on cellulose film for hemodialysis, acrylic acid (AAc), 2-hydroxyethyl methacrylate (HEMA), and the three kinds of polyethylene glycol methacrylates (PEGMAs) were grafted onto the cellulose film surface by radiation grafting technique, And then heparin was introduced onto the grafted cellulose film surfaes. The grafting and heparinization were confirmed by Fourier transform infrared spectroscopy in the attenuated total reflectance mode (FTIR-ATR) and electron spectroscopy for chemical analysis (ESCA). The blood compatibility of heparin-introduced cellulose film surfaces after grafting was examined by the detemination of platelet adhesion and thrombus formation. And the determination of platelet adhesion and thrombus formation was investigated by Imai and Nose method and field emission scanning electron microscopy (FE-SEM), respectively. The degree of platelet adhesion and thrombus formation on the samples was lower than that of control cellulose.