화학공학소재연구정보센터
Journal of Chemical and Engineering Data, Vol.61, No.1, 565-570, 2016
Liquid-Liquid Equilibrium in an Aqueous Two-Phase System of Polyethylene Glycol 6000, Sodium Sulfate, Water, Glucose, and Penicillin-G: Experimental and Thermodynamic Modeling
Aqueous two-phase systems can be applied to a penicillin fermentation process to extract the produced penicillin from the fermentation broth to achieve a higher production rate. Such systems contain a polymer and a salt or two polymers. In this study, the liquid-liquid equilibrium of the quinary system of polyethylene glycol 6000, sodium sulfate, glucose, penicillin G, and water at 298.15 K is investigated. The experimental partition coefficients of glucose and penicillin-G showed the high efficiency of the present extractive fermentation processes. Using the liquid-liquid equilibrium data, the parameters of the NRTL activity model were calculated for the quinary system. The average absolute relative deviation of 0.677 % between experimental and calculated mass fractions shows that the NRTL activity model has a good ability to predict the equilibrium concentrations of the present system. In addition, a simple and accurate turbidimetric method for the measurement of penicillin G is proposed.