Canadian Journal of Chemical Engineering, Vol.93, No.6, 1053-1062, 2015
A modelling study of a new malignant hyperthermia diagnosis device
This paper presents a mathematical model for better understanding of the functionality of a newly-proposed Malignant Hyperthermia (MH) diagnosis device. MH is a rare life-threatening condition that is usually triggered by exposure to certain drugs such as a volatile anesthetic agent, neuromuscular blocking agent, or succinylcholine. It is highly recommended to have this condition diagnosed immediately after its common symptoms appear. However, it is often only when the patient has had a severe or fatal reaction to anesthetic that a diagnosis is finally made. Due to this, many deaths have been reported before a patient has been diagnosed with this condition. Further for the diagnosis, the patients are subject to an expensive clinical diagnostic procedure and it is also necessary to continuously monitor the condition. In this study, a micro-total analysis system for MH diagnosis through the assessment of the end-tidal CO2 concentration level that can also aid point-of-care testing is presented. Various model parameters of the system are considered and their effects on the behaviour of the system are assessed. The results presented in this study are based on the proposed mathematical model for the new MH diagnosis device and can be used to evaluate the device's functionality and performance prior to its manufacture.