화학공학소재연구정보센터
Applied Surface Science, Vol.332, 368-378, 2015
Biomimetic hierarchical growth and self-assembly of hydroxyapatite/titania nanocomposite coatings and their biomedical applications
This article describes a systematic study of the biomimetic hierarchical growth of hydroxyapatite (HA)/titania (TiO2) nanocompo site layered coatings applied by a simple sol-gel dip coating method. Highly stable HA and TiO2 sols were prepared prior to inducing biomimetic hierarchical growth. Initially, the samples formed a small leaflike structure; however, increasing the dipping cycle resulted in formation of an elongated seed-like structure. Increasing the number of dipping cycles further resulted in a 'bowtie' or straw-bale like nanowire structure with a length of 500 nm and a width of 100 nm. Each nanowire like structure had a width of very few nanometers. The crystalline structures, micro/nano structures and surface properties of the coatings were characterized by X-ray diffraction, scanning electron microscopy and atomic force microscopy respectively. In vitro cellular assays revealed that the growth of the cells in the 'bowtie' like structure improved over other samples. (C) 2015 Elsevier B.V. All rights reserved.