화학공학소재연구정보센터
Journal of Supercritical Fluids, Vol.95, 17-23, 2014
Solubility of niflumic acid and celecoxib in supercritical carbon dioxide
The solubility data of two fluorinated and non-steroidal anti-inflammatory drugs, niflumic acid (CAS No. 4394-00-7) and celecoxib (CAS No. 169590-42-5), in supercritical carbon dioxide were measured with a semi-flow type phase equilibrium apparatus at temperatures ranging from 313.2 K to 353.2 K and pressures up to 31 MPa. At the highest extraction temperature and pressure, the solubilities are 2.09 x 10(-5) and 1.52 x 10(-5) in mole fraction for niflumic acid and celecoxib, respectively. The saturated solubility data were correlated with the Chrastil model, the Mendez-Santiago-Teja equation, and the Peng-Robinson equation of state. The Chrastil model fitted the experimental data to about within the experimental uncertainty. The correlated results of the Mendez-Santiago-Teja model confirmed the consistency of the solubility data over the entire experimental conditions. Incorporating with two-parameter van der Waals one-fluid mixing rules, the Peng-Robinson equation of state represents satisfactorily the gas-solid equilibrium behavior of niflumic acid and celecoxib in supercritical carbon dioxide. (C) 2014 Elsevier B.V. All rights reserved.