화학공학소재연구정보센터
Biochemical and Biophysical Research Communications, Vol.453, No.3, 432-437, 2014
The human mitotic kinesin KIF18A binds protein phosphatase 1 (PP1) through a highly conserved docking motif
Protein phosphatase 1 (PPI), a serine/threonine protein phosphatase, controls diverse key cellular events. PP1 catalytic subunits form complexes with a variety of interacting proteins that control its ability to dephosphorylate substrates. Here we show that the human mitotic kinesin-8, KIF18A, directly interacts with PP1 gamma through a conserved RVxF motif. Our phylogenetic analyses of the kinesins further uncovered the broad conservation of this interaction potential within the otherwise highly diverse motor-protein superfamily. This suggests an ancestral origin of PP1 recruitment to KIF18A and a strategic role in human mitotic cells. (C) 2014 Elsevier Inc. All rights reserved.