화학공학소재연구정보센터
Journal of the American Chemical Society, Vol.136, No.15, 5627-5630, 2014
Catalytic Asymmetric Bromoetherification and Desymmetrization of Olefinic 1,3-Diols with C-2-Symmetric Sulfides
An enantioselective and highly diastereoselective bromoetherification and desymmetrization of olefinic 1,3-diols has been developed using a C-2-symmetric cyclic sulfide catalyst. This methodology has been successfully applied to the synthesis of the key intermediate of an orally active antifungal drug posaconazole (Noxafil).