화학공학소재연구정보센터
Chemical Physics Letters, Vol.592, 80-84, 2014
Acoustic and thermal anomalies in a liquid-glass transition of racemic S(+)-R(-) ketoprofen
Acoustic and thermal properties of pharmaceutical racemic S(+)-R(-) ketoprofen were investigated in wide temperature range including glassy, supercooled liquid and liquid states by Brillouin scattering and temperature modulated DSC. Sound velocity and acoustic attenuation exhibited clear changes at 265 K indicating a liquid-glass transition and showed the typical structural relaxation above T-g. The high value of the fragility index m = 71 was determined by the dispersion of the complex heat capacity. New relaxation map was suggested in combination with previous study of dielectric measurement. (C) 2013 Elsevier B.V. All rights reserved.