화학공학소재연구정보센터
Journal of Bioscience and Bioengineering, Vol.117, No.6, 676-679, 2014
Galactosylation of human erythropoietin produced by chimeric chickens expressing galactosyltransferase
Human erythropoietin produced in the egg white of chimeric chicken contains N-glycan with lower amounts of terminal galactose and sialic acid; therefore, the chicken galactosyltransferase gene was introduced together with the human erythropoietin gene by a retroviral vector. We found that erythropoietin accumulated in the egg white was partially galactosylated. (C) 2013, The Society for Biotechnology, Japan. All rights reserved.