화학공학소재연구정보센터
Nano Today, Vol.4, No.5, 399-413, 2009
Molecular imaging and therapy of cancer with radiolabeled nanoparticles
This review summarizes the current state-of-the-art of radiolabeled nanoparticles for molecular imaging and internal radiotherapy applications targeting cancer. With the capacity to provide enormous flexibility, radiolabeled nanoparticles have the potential to profoundly impact disease diagnosis and patient management in the near future. Currently, the major challenges facing the research on radiolabeled nanoparticles are desirable (tumor) targeting efficacy, robust chemistry for both radionuclide encapsulation/incorporation and targeting ligand conjugation, favorable safety profile, as well as certain commercial and regulatory hurdles. (C) 2009 Elsevier Ltd. All rights reserved.